DUSEL offers the unique potential to explore a wide range of science in the world's deepest underground laboratory. Specific basic research topics include solar, atmospheric, long-baseline, supernova and high energy astrophysical neutrinos; double beta decay; precision assay of radionucleides, with applications ranging from disarmament treaties to environmental effluent studies; materials science; nuclear astrophysics cross-section measurements; multiple topics in geoscience and the study of the evolution of biological organisms under harsh conditions.